2015-至今：中国科学院生物与化学交叉研究中心，研究员、课题组长

Interdisciplinary Research Center on Biology and Chemistry, Chinese Academy of Sciences, Shanghai

2013-2015：耶鲁大学医学院，副研究科学家

Associate Research Scientist, Yale University School of Medicine, New Haven, Connecticut

2009-2012：美国国立卫生研究院，博士后

Postdoctoral Fellow, National Institutes of Health (NIH), Bethesda, Maryland

2004-2009：中国科学院生物物理研究所，生物化学博士

Ph.D., Institute of Biophysics, Chinese Academy of Sciences, Beijing

2000-2004: 山东大学生物科学系，理学学士

B.Sc., College of Life Sciences, Shandong University, Jinan

Representative publications (*corresponding author)

1.    Ji J, Cui MK, Zou R, Wu MZ, Ge MX, Li J, & Zhang ZR*. (2024) An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins. Molecular Cell, 84, 1917-1931

²  Highlighted with commentary by Ramanujan Hegde: Getting Membrane Proteins into Shape. Molecular Cell, 84,1821-1823

2.    Hu X, Zou R, Zhang Z, Ji J, Li J, Huo XY, Liu D, Ge MX, Cui MK, Wu MZ, Li ZP, Wang Q, Zhang X & Zhang ZR*. (2023) UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. Biochim Biophys Acta Gene Regul Mech. 1866: 194937

3.    Wang L, Li J, Wang Q, Ge MX, Ji J, Liu D, Wang Z, Cao Y, Zhang Y & Zhang ZR*. (2022) TMUB1 is an endoplasmic reticulum-resident escortase that promotes p97-mediated extraction of membrane proteins for degradation. Molecular Cell 82, 3453-3467

4.    Hu X, Wang L, Wang Y, Ji J, Li J, Wang Z, Li C, Zhang Y & Zhang ZR*. (2020) RNF126-mediated reubiquitination is required for proteasomal degradation of p97-extracted membrane proteins. Molecular Cell 79, 320-331

²  Highlighted with commentary by Claudia Schmidt and Alexander Stein: Off and On Again: De- and Reubiquitination during Membrane Protein Degradation. Molecular Cell, 79,203-204

5.    Shi J, Hu X, Guo Y, Wang L, Ji J, Li J & Zhang ZR*. (2019) A technique for delineating the unfolding requirements for substrate entry into retrotranslocons during endoplasmic reticulum-associated degradation. J Biol Chem. 294, 20084-20096. Recommended in Faculty of 1000

6.    Zhang ZR*, Bonifacino JS & Hegde RS*. (2013) Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER. Cell 154, 609-622,

²  Highlighted with commentary by Jeffrey Brodsky: Just a trim, please: refining ER degradation through deubiquitination. Cell, 154,479-481

Other publications (#first author):

1.    Zhang M, Wang Z, Zhao Q, Yang Q, Bai J, Yang C, Zhang ZR, Liu Y*. (2024) USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy. Autophagy. Online ahead of print.

2.    Hou X, Zhang X, Zou H, Guan M, Fu C, Wang W, Zhang ZR, Geng Y* & Chen Y*. (2023) Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4. Neuron. 111, 1898-1913

3.    Liang W, Qi W, Geng Y, Wang L, Zhao J, Zhu K, Wu G, Zhang ZR, Pan H, Qian L & Yuan J*. (2021) Necroptosis activates UPR sensors without disrupting their binding with GRP78. Proc Natl Acad Sci USA. 118 (39): e2110476118.

4.    Coelho JPL, Stahl M, Bloemeke N, Meighen-Berger K, Alvira CP, Zhang ZR, Sieber SA & Feige MJ*. (2019) A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration. Nat Commun. 10, 672.

5.    Plumb R^#, Zhang ZR^#, Appathurai S & Mariappan M*. (2015) A functional link between the co-translational protein translocation pathway and the UPR. eLife 4, e07426 (#co-first author)

6.    Park SY, Waheed AA, Zhang ZR, Freed EO & Bonifacino JS*. (2014) HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor. J. Biol. Chem. 289, 35102-35110

7.    Moran C, Kinsella GK, Zhang ZR, Perrett S & Jones GW*. (2013) Mutational Analysis of Sse1 (Hsp110) Suggests an Integral Role for this Chaperone in Yeast Prion Propagation In Vivo. G3: Genes, Genomes, Genetics 3, 1409-1418

8.    Emerman AB, Zhang ZR, Chakrabarti O & Hegde RS*. (2010). Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo. Mol. Biol. Cell 21, 4325-4337

9.    Zhang C, Jackson A, Zhang ZR, Han Y, Yu S, He RQ & Perrett S*. (2010). Amyloid-Like aggregates of the yeast prion protein Ure2 enter vertebrate cells by specific endocytotic pathways and induce apoptosis. PLoS ONE 5, e12529

10.  Zhang ZR^# & Perrett S*. (2009). Novel glutaredoxin activity of the yeast prion protein Ure2 reveals a native-like dimer within fibrils. J. Biol. Chem. 284, 14058-14067

11.  Wang XY, Zhang ZR & Perrett S*. (2009). Characterization of the activity and folding of the glutathione transferase from Escherichia coli and the roles of residues Cys10 and His106. Biochem. J. 417, 55-64

12.  Zhang ZR^#, Bai M, Wang XY, Zhou JM & Perrett S*. (2008). "Restoration" of glutathione transferase activity by single-site mutation of the yeast prion protein Ure2. J. Mol. Biol. 384, 641-651

13.  Lian HY, Zhang H, Zhang ZR, Loovers HM, Jones GW, Rowling PJ, Itzhaki LS, Zhou JM & Perrett S*. (2007). Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. J. Biol. Chem. 282, 11931-11940