1999.9-2003.7 北京大学化学与分子工程学院，获理学学士学位；
2003.9-2008.7 中国科学院上海有机化学研究所，获哲（理）学博士学位；
2008.9-2013.6 美国哈佛大学医学院细胞生物学系，博士后；
2013.7- 中国科学院上海有机化学研究所生物与化学交叉研究中心，副研究员。

1.      Xu, G^#.;  Li, Y.^#;  Zhang, S^#.;  Peng, H.^#;  Wang, Y.^#;  Li, D.;  Jin, T.;  He, Z.;  Tong, Y.;  Qi, C.;  Wu, G.;  Dong, K.;  Gou, J.;  Liu, Y.;  Xiao, T.;  Qu, J.;  Li, L.^*;  Liu, L.^*;  Zhao, P.^*;  Zhang, Z.^*; Yuan, J.^*, SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. Cell Res 2021, 31 (12), 1230-1243.

2.      Mei, X.;  Guo, Y.;  Xie, Z.;  Zhong, Y.;  Wu, X.;  Xu, D.;  Li, Y.;  Liu, N.; Zhu, Z. J., RIPK1 regulates starvation resistance by modulating aspartate catabolism. Nat Commun 2021, 12 (1), 6144.

3.      Wang, H.;  Qi, W.;  Zou, C.;  Xie, Z.;  Zhang, M.;  Naito, M. G.;  Mifflin, L.;  Liu, Z.;  Najafov, A.;  Pan, H.;  Shan, B.;  Li, Y.;  Zhu, Z. J.; Yuan, J., NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation. Nat Commun 2021, 12 (1), 4826.

4.      Meng, H.^#;  Wu, G.^#;  Zhao, X.^#;  Wang, A.^#;  Li, D.;  Tong, Y.;  Jin, T.;  Cao, Y.;  Shan, B.;  Hu, S.;  Li, Y.;  Pan, L.;  Tian, X.;  Wu, P.;  Peng, C.;  Yuan, J.;  Li, G.^*;  Tan, L.^*;  Wang, Z.^*; Li, Y.^*, Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov 2021, 7 (1), 41.

5.      Shan, H.^#;  Liu, J.^#;  Shen, J.^#;  Dai, J.^#;  Xu, G.^#;  Lu, K.;  Han, C.;  Wang, Y.;  Xu, X.;  Tong, Y.;  Xiang, H.;  Ai, Z.;  Zhuang, G.;  Hu, J.;  Zhang, Z.^*;  Li, Y.^*;  Pan, L.^*; Tan, L.^*, Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol 2021, 28 (6), 855-865 e9.

6.      Liu, Z.;  Zhang, S.;  Gu, J.;  Tong, Y.;  Li, Y.;  Gui, X.;  Long, H.;  Wang, C.;  Zhao, C.;  Lu, J.;  He, L.;  Li, Y.;  Liu, Z.;  Li, D.; Liu, C., Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation. Nat Struct Mol Biol 2020, 27 (4), 363-372.

7.      Najafov, A.;  Mookhtiar, A. K.;  Luu, H. S.;  Ordureau, A.;  Pan, H.;  Amin, P. P.;  Li, Y.;  Lu, Q.; Yuan, J., TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL. Mol Cell 2019, 75 (3), 457-468 e4.

8.      Chen, G.;  Niu, C.;  Yi, J.;  Sun, L.;  Cao, H.;  Fang, Y.;  Jin, T.;  Li, Y.;  Lou, C.;  Kang, J.;  Wei, W.; Zhu, J., Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers. J Med Chem 2019, 62 (6), 3107-3121.

9.      Xu, D.;  Jin, T.;  Zhu, H.;  Chen, H.;  Ofengeim, D.;  Zou, C.;  Mifflin, L.;  Pan, L.;  Amin, P.;  Li, W.;  Shan, B.;  Naito, M. G.;  Meng, H.;  Li, Y.;  Pan, H.;  Aron, L.;  Adiconis, X.;  Levin, J. Z.;  Yankner, B. A.; Yuan, J., TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell 2018, 174 (6), 1477-1491 e19.

10.    Meng, H.;  Liu, Z.;  Li, X.;  Wang, H.;  Jin, T.;  Wu, G.;  Shan, B.;  Christofferson, D. E.;  Qi, C.;  Yu, Q.;  Li, Y.^*; Yuan, J.^*, Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Proc Natl Acad Sci U S A 2018, 115 (9), E2001-E2009.

11.    Huang, H. T.;  Dobrovolsky, D.;  Paulk, J.;  Yang, G.;  Weisberg, E. L.;  Doctor, Z. M.;  Buckley, D. L.;  Cho, J. H.;  Ko, E.;  Jang, J.;  Shi, K.;  Choi, H. G.;  Griffin, J. D.;  Li, Y.;  Treon, S. P.;  Fischer, E. S.;  Bradner, J. E.;  Tan, L.; Gray, N. S., A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chem Biol 2018, 25 (1), 88-99 e6.

12.    Wang, H.;  Meng, H.;  Li, X.;  Zhu, K.;  Dong, K.;  Mookhtiar, A. K.;  Wei, H.;  Li, Y.;  Sun, S. C.; Yuan, J., PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proc Natl Acad Sci U S A 2017, 114 (45), 11944-11949.

13.    Li, Y.; Yuan, J., Systematic Metrics Depicting Cell Death Kinetics. Cell Chem Biol 2017, 24 (7), 785-786.

14.    Li, Y.;  Qian, L.; Yuan, J., Small molecule probes for cellular death machines. Curr Opin Chem Biol 2017, 39, 74-82.

15.    Ito, Y.;  Ofengeim, D.;  Najafov, A.;  Das, S.;  Saberi, S.;  Li, Y.;  Hitomi, J.;  Zhu, H.;  Chen, H.;  Mayo, L.;  Geng, J.;  Amin, P.;  DeWitt, J. P.;  Mookhtiar, A. K.;  Florez, M.;  Ouchida, A. T.;  Fan, J. B.;  Pasparakis, M.;  Kelliher, M. A.;  Ravits, J.; Yuan, J., RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science 2016, 353 (6299), 603-8.

16.    Xu, D.;  Zhang, T.;  Xiao, J.;  Zhu, K.;  Wei, R.;  Wu, Z.;  Meng, H.;  Li, Y.; Yuan, J., Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon. Autophagy 2015, 11 (4), 617-28.

17.    Christofferson, D. E.;  Li, Y.; Yuan, J., Necrostatin-1: Its Discovery and Application in Cell Death Research. In Necrotic Cell Death, Shen, H.-M.; Vandenabeele, P., Eds. Springer New York: New York, NY, 2014; pp 295-318.

18.    Christofferson, D. E.;  Li, Y.; Yuan, J., Control of life-or-death decisions by RIP1 kinase. Annu Rev Physiol 2014, 76, 129-50.

19.    Wu, Z.;  Li, Y.;  Cai, Y.;  Yuan, J.; Yuan, C., A novel necroptosis inhibitor-necrostatin-21 and its SAR study. Bioorg Med Chem Lett 2013, 23 (17), 4903-6.

20.    Christofferson, D. E.;  Li, Y.;  Hitomi, J.;  Zhou, W.;  Upperman, C.;  Zhu, H.;  Gerber, S. A.;  Gygi, S.; Yuan, J., A novel role for RIP1 kinase in mediating TNFalpha production. Cell Death Dis 2012, 3, e320.

21.    Liu, J.;  Xia, H.;  Kim, M.;  Xu, L.;  Li, Y.;  Zhang, L.;  Cai, Y.;  Norberg, H. V.;  Zhang, T.;  Furuya, T.;  Jin, M.;  Zhu, Z.;  Wang, H.;  Yu, J.;  Li, Y.;  Hao, Y.;  Choi, A.;  Ke, H.;  Ma, D.; Yuan, J., Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 2011, 147 (1), 223-34.

22.    Chen, Z.;  Ma, X.;  Zhang, H.;  Sun, X.;  Shen, S.;  Li, Y.;  Gu, Y.;  Wang, Y.;  Yan, S.; Yu, Q., Negative regulation of interferon-gamma/STAT1 signaling through cell adhesion and cell density-dependent STAT1 dephosphorylation. Cell Signal 2011, 23 (8), 1404-12.

23.    Shen, S.;  Zhang, P.;  Lovchik, M. A.;  Li, Y.;  Tang, L.;  Chen, Z.;  Zeng, R.;  Ma, D.;  Yuan, J.; Yu, Q., Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy. J Cell Biol 2009, 185 (4), 629-39.

24.    Yan, S. S.;  Li, Y.;  Wang, Y.;  Shen, S. S.;  Gu, Y.;  Wang, H. B.;  Qin, G. W.; Yu, Q., 17-Acetoxyjolkinolide B irreversibly inhibits IkappaB kinase and induces apoptosis of tumor cells. Mol Cancer Ther 2008, 7 (6), 1523-32.